This weekend, directing duo Hannah Marks and Joey Power make their feature debut with a film from a cinematic genre with a surprisingly long history—the cancer drama. After Everything follows the 23-year-old Elliot (Shameless’ Jeremy Allen White), who receives a damning diagnosis and meets love interest Mia (It Follows’ Maika Monroe) in the same week. At the premiere of After Everything, we sat down with Marks and Power to discuss how they distinguished their film from other cancer dramas, and talk about the often undiscussed realities of living with a cancer diagnosis.